While international news has dominated the headlines this week, we all need to keep our attention focused on the proposed cuts to National Institues of Health funding included in the FY 2018 budget template released by the U.S. presidential administration. The new budget takes effect October 1. If the draconian 18 percent cut proposed for the NIH budget should survive the budget development process, the negative impact on science would be unprecedented and difficult to fully appreciate. In current dollar terms, the template calls for a $5.8 billion cut to NIH’s current $31.7 billion budget.